Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia.
They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Although awareness of familial hypercholesterolemia (FH) is increasing, this common, potentially
fatal, treatable condition remains underdiagnosed. Despite FH being a genetic disorder…

Background Premature coronary artery disease is a major cause of illness and death in patients
with systemic lupus erythematosus, but little is known about the prevalence, extent, and …

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages,
and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice …

The adipocyte fatty-acid–binding protein, aP2, has an important role in regulating systemic
insulin resistance and lipid metabolism. Here we demonstrate that aP2 is also expressed in …

Atherosclerosis may be viewed as an inflammatory disease process that includes early
oxidative modification of LDLs, leading to foam cell formation. This “oxidation hypothesis” has …

Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals
associated with atherosclerosis, although the pathophysiological importance and the …

Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in
humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin…

Objective— Atherosclerosis is an inflammatory disease characterized by innate and adaptive
immune responses. We investigated the role of B cells and antibodies in the development …