CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32. 1
…, T Okamoto, M Taniwaki, M Aizawa, M Inoue… - Nature …, 1994 - nature.com
We have identified a novel gene containing CAG repeats and mapped it to chromosome
14q32.1, the genetic locus for Machado-Joseph disease (MJD). In normal individuals the gene …
14q32.1, the genetic locus for Machado-Joseph disease (MJD). In normal individuals the gene …
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and …
Y Kanda, T Yamada, K Mori, A Okazaki, M Inoue… - …, 2007 - academic.oup.com
The structure of asparagine-linked oligosaccharides attached to the antibody constant region
(Fc) of human immunoglobulin G1 (IgG1) has been shown to affect the pharmacokinetics …
(Fc) of human immunoglobulin G1 (IgG1) has been shown to affect the pharmacokinetics …
Comparison of cell lines for stable production of fucose‐negative antibodies with enhanced ADCC
…, K Yamano, R Nakano, M Inoue… - Biotechnology and …, 2006 - Wiley Online Library
Several methods have been described to enhance antibody‐dependent cellular cytotoxicity
(ADCC) using different host cells that produce antibody with reduced levels of fucose on …
(ADCC) using different host cells that produce antibody with reduced levels of fucose on …
Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high …
S Iida, H Misaka, M Inoue, M Shibata, R Nakano… - Clinical cancer …, 2006 - AACR
Purpose: Recent studies have revealed that fucosylated therapeutic IgG1s need high
concentrations to compensate for FcγRIIIa-competitive inhibition of antibody-dependent cellular …
concentrations to compensate for FcγRIIIa-competitive inhibition of antibody-dependent cellular …
[HTML][HTML] Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating …
H Imai-Nishiya, K Mori, M Inoue, M Wakitani, S Iida… - BMC …, 2007 - Springer
Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the
absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the …
absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the …
Establishment of a GDP-mannose 4, 6-dehydratase (GMD) knockout host cell line: a new strategy for generating completely non-fucosylated recombinant therapeutics
…, H Imai-Nishiya, R Kuni-Kamochi, K Mori, M Inoue… - Journal of …, 2007 - Elsevier
Currently, removal of core fucose from the Fc oligosaccharides of therapeutic antibodies is
widely recognized as being of great importance for the effector function of antibody-…
widely recognized as being of great importance for the effector function of antibody-…
[HTML][HTML] CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin α5β1
M Hoshijima, T Hattori, M Inoue, D Araki, H Hanagata… - FEBS letters, 2006 - Elsevier
Searching for CCN family protein 2/connective tissue growth factor (CCN2/CTGF) interactive
proteins by yeast-two-hybrid screening, we identified fibronectin 1 gene product as a major …
proteins by yeast-two-hybrid screening, we identified fibronectin 1 gene product as a major …
Cost-effectiveness analysis of recurrence score-guided treatment using a 21-gene assay in early breast cancer
DT Tsoi, M Inoue, CM Kelly, S Verma… - The oncologist, 2010 - academic.oup.com
Purpose. Most guidelines for hormone receptor (HR)–positive early breast cancer recommend
addition of adjuvant chemotherapy for most women, leading to overtreatment, which …
addition of adjuvant chemotherapy for most women, leading to overtreatment, which …
[HTML][HTML] Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood
S Iida, R Kuni-Kamochi, K Mori, H Misaka, M Inoue… - BMC cancer, 2009 - Springer
Background Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified
as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, …
as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, …
[HTML][HTML] CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception
…, T Iwasa, M Oshima, M Hosoki, M Inoue… - International journal of …, 2019 - mdpi.com
Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG)
secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates …
secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates …