Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular
entities focused on ‘small’ chemical compounds. The molecular entities in question are either …

During the last 3 years, a number of approaches for the normalization of RNA sequencing
data have emerged in the literature, differing both in the type of bias adjustment and in the …

There is currently no approved treatment for primary Sjögren’s syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is -in part- because …

Background TNFAIP3 encodes the ubiquitin-modifying enzyme, a key regulator of
inflammatory signalling pathways. Convincing associations between TNFAIP3 variants and …

Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies
with life science technologies to capture the value of massive multi-modal data in the form of …

Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced
development of drug resistance and owing to these advantages, have become a standard …

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and
motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of …

High-throughput post-genomic studies are now routinely and promisingly investigated in
biological and biomedical research. The main statistical approach to select genes differentially …

Islet-1 (Isl1) is a member of the Isl1 family of LIM-homeodomain transcription factors (LIM-HD)
that is expressed in a defined subset of motor and sensory neurons during vertebrate …

Background Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited
neuropathy caused by an autosomal dominant duplication of a gene encoding for the structural …