OBJECTIVE To define the pattern of mRNA expression of all human matrix metalloproteinases
(MMPs) described to date in rheumatoid arthritis (RA) and traumatic synovial membrane, …

The aim of this study was to investigate the extracellular degrading proteolytic cascade
proteins referred to as matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-9, membrane-type …

The generation of wear debris is an inevitable result of normal usage of joint replacements.
Wear debris particles stimulate local and systemic biological reactions resulting in chronic …

Objective To measure cartilage pH in patients with osteoarthritis (OA) and to analyze the
presence of cathepsin K, the recently discovered acidic endoproteinase, in phenotypically …

The metal stem of the totally replaced hip carries load and resists fatigue, but it is
electrochemically corroded. Metallic atoms act as haptens, induce type 1 T-helper cells/Th1-type …

We studied the possible use of silicon carbide (SiC) as a ceramic coating material of titanium-based
total hip replacement (THR) implants. The idea is to prevent wear debris formation …

PURPOSE: To determine the earliest findings, subsequent changes, and natural course of
osteochondritis dissecans of the humeral capitellum. MATERIALS AND METHODS: Among …

Total joint replacement is one of the most clinically successful, cost‐effective surgical procedures.
These operations have been shown to improve pain, function and mobility in patients …

Normal bone remodeling and pathological bone destruction have been considered to be
osteoclast‐driven. Osteoclasts are able to attach to bare bone surface and produce an acidic …

Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to
femoral head collapse and subsequently, degenerative arthritis. Although injection of bone …