Mosaic organization of DNA nucleotides

CK Peng, SV Buldyrev, S Havlin, M Simons… - Physical review e, 1994 - APS
Long-range power-law correlations have been reported recently for DNA sequences
containing noncoding regions. We address the question of whether such correlations may be a …

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

M Simons, ER Edelman, JL DeKeyser, R Langer… - Nature, 1992 - nature.com
SYNTHETIC antisense oligonucleotides have been used to dissect gene function in vitro.
Technical difficulties prevented the use of this approach for investigating the effect of gene …

Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial

M Simons, BH Annex, RJ Laham, N Kleiman, T Henry… - Circulation, 2002 - Am Heart Assoc
Background— Single-bolus intracoronary administration of fibroblast growth factor-2 (FGF2)
improved symptoms and myocardial function in a phase I, open-label trial in patients with …

Long-range correlations in nucleotide sequences

…, AL Goldberger, S Havlin, F Sciortino, M Simons… - Nature, 1992 - nature.com
DNA SEQUENCES have been analysed using models, such as an it-step Markov chain,
that incorporate the possibility of short-range nucleotide correlations 1 . We propose here a …

Mechanisms and regulation of endothelial VEGF receptor signalling

M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and remodelling …

[HTML][HTML] Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

…, B Gallez, MG Lampugnani, E Dejana, M Simons… - Cell, 2009 - cell.com
A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities
in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate …

Clinical trials in coronary angiogenesis: issues, problems, consensus: an expert panel summary

M Simons, RO Bonow, NA Chronos, DJ Cohen… - Circulation, 2000 - Am Heart Assoc
The rapid development of angiogenic growth factor therapy for patients with advanced
ischemic heart disease over the last 5 years offers hope of a new treatment strategy based on …

Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction …

A Braun, BL Trigatti, MJ Post, K Sato, M Simons… - Circulation …, 2002 - Am Heart Assoc
Murine models of atherosclerosis, such as the apolipoprotein E (apoE) or the LDL receptor
knockout mice, usually do not exhibit many of the cardinal features of human coronary heart …

Endothelial cell metabolism in normal and diseased vasculature

G Eelen, P De Zeeuw, M Simons… - Circulation research, 2015 - Am Heart Assoc
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels
supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies …

Role of angiogenesis in cardiovascular disease: a critical appraisal

R Khurana, M Simons, JF Martin, IC Zachary - Circulation, 2005 - Am Heart Assoc
The role of angiogenesis in atherosclerosis and other cardiovascular diseases has
emerged as a major unresolved issue. Angiogenesis has attracted interest from opposite …