Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. Synovial fluid scavenging effect is enhanced in rheumatoid arthritis …

…, F Sekine, K Kobayashi, M Negishi… - … : Official Journal of …, 1988 - Wiley Online Library
To test the scavenging of reactive oxygen species (ROS), we added synovial fluids from
patients with rheumatoid arthritis (RA) and osteoarthritis, as well as hyaluronic acid (HA) and its …

[HTML][HTML] A novel mechanism for the regulation of IFN-γ inducible protein-10 expression in rheumatoid arthritis

…, N Yajima, F Shiozawa, Y Miwa, M Negishi… - Arthritis Res Ther, 2003 - Springer
Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the
present study we examined the expression and regulatory mechanisms of IFN-γ inducible …

Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis

…, F Shiozawa, M Hanyuda, M Negishi… - The Journal of …, 2000 - journals.aai.org
We have examined the expression and function of the angiogenic factor, vascular
endothelial growth factor (VEGF) during the evolution of type II collagen-induced arthritis (CIA). …

Elevated levels of soluble fractalkine in active systemic lupus erythematosus: potential involvement in neuropsychiatric manifestations

…, T Odai, M Matsunawa, M Negishi… - Arthritis & …, 2005 - Wiley Online Library
Objective To determine levels of the soluble form of the chemokine fractalkine (sFkn) and its
receptor, CX 3 CR1, in patients with systemic lupus erythematosus (SLE) with …

Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis

…, N Yajima, HT Takeuchi, M Negishi… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To determine levels of soluble fractalkine (sFkn) in rheumatoid arthritis (RA) patients
with and without rheumatoid vasculitis (RV), and to assess the relationship of sFkn levels …

Clinical evaluation of patients with inflammatory connective tissue diseases complicated by cytomegalovirus antigenemia

…, N Yajima, F Shiozawa, Y Miwa, M Negishi… - Modern …, 2006 - Taylor & Francis
We evaluated the occurrence of cytomegalovirus (CMV) infection and the background
characteristics in twenty-three hospitalized patients with inflammatory connective tissue diseases …

Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: critical involvement of the interaction with synovial fibroblasts

…, HT Takeuchi, Y Mori, M Negishi… - Arthritis & …, 2001 - Wiley Online Library
Objective To examine the expression and regulation of the angiogenic factor, vascular
endothelial growth factor (VEGF), by fibroblast‐like synoviocytes (FLS), monocytes, and …

Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis

…, L Jing, Y Mori, K Kobayashi, M Negishi… - Annals of the …, 1999 - ard.bmj.com
OBJECTIVE To determine the contribution made by synovial fluid (SF) neutrophils to the
augmented expression of macrophage inflammatory protein 1 α (MIP-1α) in rheumatoid arthritis (…

Clinical features of hemophagocytic syndrome in patients with dermatomyositis

…, T Isozaki, M Matsunawa, Y Miwa, M Negishi… - The Journal of …, 2008 - jrheum.org
Objective To investigate the clinical features of patients with dermatomyositis (DM) complicated
by hemophagocytic syndrome (HPS). Methods Twenty-four patients diagnosed with DM …

Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin 1 and …

…, T Fukushima, M Tabata, I Ohno, M Negishi… - Clinical immunology and …, 1989 - Elsevier
In the present study, we investigated the possibility that oxidative stress to human peripheral
blood monocytes and polymorphonuclear leukocytes (PMNs) can induce interleukin 1 (IL-1)-…