Cbfa1 is a transcription factor that belongs to the runt domain gene family. Cbfa1-deficient
mice showed a complete lack of bone formation due to the maturational arrest of osteoblasts, …

Background: Tumor necrosis factor‐α (TNF‐α) may play an important role in insulin resistance.
In this study, we hypothesized that TNF‐α produced due to periodontal inflammation …

During skeletogenesis, cartilage develops to either permanent cartilage that persists through
life or transient cartilage that is eventually replaced by bone. However, the mechanism by …

Studies have suggested that continuous Wnt/β-catenin signaling in nascent cartilaginous
skeletal elements blocks chondrocyte hypertrophy and endochondral ossification, whereas …

The origin, roles and fate of progenitor cells forming synovial joints during limb skeletogenesis
remain largely unclear. Here we produced prenatal and postnatal genetic cell fate-maps …

Heterotopic ossification consists of ectopic bone formation within soft tissues after surgery or
trauma. It can have debilitating consequences, but there is no definitive cure. Here we show …

Synovial joints are elegant, critically important, and deceptively simple biomechanical structures.
They are comprised of articular cartilage that covers each end of the opposing skeletal …

In this study we asked whether members of thehedgehoggene family are involved in
osteogenesis. C3H10T1/2 cells and MC3T3-E1 cells expressed the putative hedgehog …

A fine balance between anabolic and catabolic mechanisms maintains extracellular matrix
homeostasis in articular cartilage, and shifts toward degradation are associated with joint …

Rabbit chondrocyte cultures on plastic dishes are capable of depositing a cartilaginous
matrix, although the matrix does not calcify unless high levels of phosphate are added to the …