Background Bone fracture initiates a series of cellular and molecular events including the
expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and …

Objective Glucocorticoids (GCs) exert their antiinflammatory and immunosuppressive effects
in humans primarily via the cytosolic GC receptor (cGR) but also via rapid, nongenomic …

Exercise at regular intervals is assumed to have a positive effect on immune functions.
Conversely, after spaceflight and under simulated weightlessness (eg, bed rest), immune …

Hypoxia, a feature of inflammation and tumors, is a potent inducer of the proinflammatory
cytokine macrophage migration inhibitory factor (MIF). In transformed cells, MIF was shown to …

Hypoxia driven angiogenesis is a prominent feature of tissue regeneration, inflammation
and tumor growth and is regulated by hypoxia-inducible factor (HIF)-1 and -2. The distinct …

Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and
therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed …

Introduction Inflammatory arthritis is a progressive disease with chronic inflammation of
joints, which is mainly characterized by the infiltration of immune cells and synovial …

Objective. Inflamed tissues are usually characterized by low oxygen levels. We investigated
whether pathophysiological hypoxia (pO 2 < 1%) as found in the rheumatoid synovium …

Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study
Page 1 Clinical and Experimental Rheumatology 2015; 33: 34-43. Circadian rhythms of cellular …

Inflamed areas are characterized by infiltration of immune cells, local hypoxia and alterations
of cellular redox states. We investigated the impact of hypoxia on survival, proliferation, …