Objective. Osteoporotic fractures are associated with significant morbidity and mortality
particularly among older men. However, there is little information regarding risk factors among …

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …

CRISPR-Cas9 genome engineering has revolutionised high-throughput functional genomic
screens. However, recent work has raised concerns regarding the performance of CRISPR-…

Under fasting conditions, metazoans maintain energy balance by shifting from glucose to fat
burning. In the fasted state, SIRT1 promotes catabolic gene expression by deacetylating the …

Cryptocurrencies are rapidly growing and are increasingly accepted by major commercial
vendors. However, along with their rising popularity, they have also become the go-to …

The starvation-inducible coactivator cAMP response element binding protein (CREB)–cAMP-regulated
transcription coactivator (Crtc) has been shown to promote starvation resistance …

Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common
cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent …

Importance Multiparametric magnetic resonance imaging (MRI) in conjunction with MRI–transrectal
ultrasound (TRUS) fusion-guided biopsies have improved the detection of prostate …

Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and
Leishmania infantum, is one of the major parasitic diseases worldwide. There is an urgent …

There is an urgent need for new treatments for visceral leishmaniasis (VL), a parasitic infection
which impacts heavily large areas of East Africa, Asia, and South America. We previously …