Objective Autoantibodies have been demonstrated in single serum samples from healthy
subjects up to 10 years before they developed rheumatoid arthritis (RA). However, the time …

Objective To examine how anti–citrullinated protein antibody (ACPA) epitope spreading takes
place prior to the onset of clinical rheumatoid arthritis (RA), and to analyze the pattern of …

OBJECTIVE: To study the diagnostic value of IgM rheumatoid factor (RF), IgA-RF, antibodies
to cyclic citrullinated peptide (anti-CCP), and combinations of these antibodies, measured …

Objectives To determine the fine specificity of anti-citrullinated protein antibodies (ACPA) in
the early phase of arthritis development, the ACPA repertoire in arthralgia patients and the …

Objective: To investigate the temporal relationship between onset of inflammation (as
measured by secretory phospholipase A 2 (sPLA 2 ) and C reactive protein (CRP)) and the …

OBJECTIVE: To assess the additional predictive value of anti-cyclic citrullinated peptide (anti-CCP)
antibodies above conventional variables for progressive erosive or disabling disease …

Objective To investigate the effect of anti-tumor necrosis factor (TNF) treatment on rheumatoid
factor (IgM-RF) and anticitrullinated protein antibodies (ACPA) and its association with …

Objective. Rheumatoid arthritis (RA) is characterized by high levels of cytokines such as
tumor necrosis factor (TNF). TNF appears to have an etiologic role in thyroid dysfunction, and …

Radiographic damage and its progression in early rheumatoid arthritis (RA) can be predicted
by markers and regulators of bone metabolism. Studies of bone formation in RA patients …

Turbimetry was used to study the influence of glycosaminoglycans of cartilage
proteoglycans on type II collagen fibrillogenesis. The monosaccharides, D-glucuronate, N-acetyl-D-…