Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Objective To investigate the association between weight or body mass index (BMI) and the
development of hand osteoarthritis. Methods Systematic review of observational studies. …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …

Purpose: To prospectively evaluate the association between clinical features and structural
abnormalities found at magnetic resonance (MR) imaging in patients with osteoarthritis (OA) …

Objective To systematically evaluate the association between MRI findings (cartilage defects,
bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous …

Since publication of the European League Against Rheumatism (EULAR) recommendations
for management of hand osteoarthritis (OA) in 2007 new evidence has emerged. The aim …

The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Objectives: To study the gene–environment interaction of tobacco exposure and shared
epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis. …