B cells mediate multiple functions that influence immune and inflammatory responses. In this
study, T cell-mediated inflammation was exaggerated in CD19-deficient (Cd19 −/− ) mice …

Objective To identify the 140‐kd autoantigen recognized by anti‐155/140 autoantibodies that
are associated with adult cancer‐associated dermatomyositis (DM) and juvenile DM and to …

B cells play critical roles in the pathogenesis of lupus. To examine the influence of B cells
on disease pathogenesis in a murine lupus model, New Zealand Black and New Zealand …

Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous
group of autoimmune disorders with varying clinical manifestations, treatment responses and …

Objective To determine phenotypic and functional abnormalities of blood B cell subsets in
patients with systemic sclerosis (SSc). Methods Cell surface marker expression was …

The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops
cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although …

T lymphocyte selection and lineage commitment in the thymus requires multiple signals.
Herein, CD4 + T cell generation required engagement of CD83, a surface molecule expressed …

CD19 regulates constitutive and antigen receptor–induced signaling thresholds in B
lymphocytes through its unique cytoplasmic domain. Herein, we demonstrate a novel molecular …

EAE is a mouse T cell–mediated autoimmune disease of the CNS used to model the human
condition MS. The contributions of B cells to EAE initiation and progression are unclear. In …

Connective tissue growth factor (CTGF) is a novel peptide that exhibits platelet-derived growth
factor-like activities and is produced by skin fibroblasts after activation with transforming …