Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Objective Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death
in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to …

Importance High-dose immunosuppressive therapy and autologous hematopoietic stem cell
transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small …

Objective. The 1980 American College of Rheuma-tology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and
internal organs that leads to profound disability and premature death. To identify new SSc …

Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology
of the microcirculation. Since its recent incorporation in the 2013 American College of …

The aim of this study was to determine, through a genome-wide association study (GWAS),
the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis …

Background In the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial,
nintedanib reduced the rate of decline in forced vital capacity (FVC) in patients with systemic …

Objective: Systemic sclerosis (SSc) is a generalised autoimmune disease, causing morbidity
and a reduced life expectancy, especially in patients with rapidly progressive diffuse …

Systemic sclerosis-associated pulmonary arterial hypertension (SScPAH) has a worse
prognosis and response to pulmonary arterial hypertension (PAH) therapy than idiopathic PAH (…