… Similar to P-LPD, chemotherapy for such aggressive cases is based on the diagnosis of
similar pathological features in M-LPD (described in the MTX-ND-LPD section). However, the …

OBJECTIVE: Acute/subacute interstitial pneumonia (A/SIP) in patients with polymyositis/dermatomyositis
(PM/DM) is frequently fatal within months despite high dose prednisolone (PSL) …

Rheumatoid arthritis (RA) is characterized by recruitment of leukocytes from the vasculature
into inflamed synovial tissue (ST) and synovial fluid (SF), which depends, in part, upon the …

Methotrexate (MTX) carries a risk of lymphoproliferative disorders (LPDs), but MTX-associated
LPDs (MTX-LPDs) can resolve spontaneously after MTX withdrawal. However, the …

The purpose of this trial was to evaluate the efficacy of 2-year consolidation therapy with
nilotinib, at a dose of 300 mg twice daily, for achieving treatment-free remission in chronic …

Medical records of five patients with sclerodenna (SSc), each of whom had pericardial effusion
with an estimated volume of more than 200 ml, were reviewed to study the clinical and …

Although recent accumulative data reveal the clinicopathogenesis of regression in
methotrexate-induced lymphoproliferative disorders (MTX-LPDs), the precise understanding …

Despite numerous attempts to uncover the mechanism of other iatrogenic immunodeficiency-associated
lymphoproliferative diseases (OIIA-LPDs), this mechanism remains poorly …

Objective. To clarify the characteristics of lymphoproliferative disorder (LPD) in patients with
RA treated with MTX. Methods. Among 33 patients developing LPD during MTX treatment, …

Integrin αIIbβ3 plays a critical role in platelet aggregation through its interaction with fibrinogen.
Elucidation of the mechanisms of αIIbβ3-fibrinogen interaction is critical to understanding …