The mechanisms of malignant cell transformation caused by the oncogenic, chimeric
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood, with …

BACKGROUND Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2)
pandemic described children as being less susceptible to coronavirus disease 2019 (…

Human herpesvirus-8 (HHV-8)–negative, idiopathic multicentric Castleman disease (iMCD)
is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal …

OBJECTIVE: Macrophage activation syndrome (MAS) is a well described, but purportedly
uncommon manifestation of systemic juvenile idiopathic arthritis (SJIA). There is evidence to …

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS)
are 2 similar diseases characterized by a cytokine storm, overwhelming inflammation, …

Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
have mild or minimal disease, with a small proportion developing severe disease or …

Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is approved
for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the impact …

We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte
globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted …

Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction
of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20–25…

Objective: To quantify inflammatory changes in synovial membranes from orthopaedic “non-inflammatory”
arthropathies (Orth. A). Methods: Synovial membranes from patients with …