The genome of the yeast Saccharomyces cerevisiae has been completely sequenced
through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential …

Our study compared point-of-care (POC) device monitoring with traditional clinical laboratory
methods device of patients on oral anticoagulant therapy. The POC devices used in the …

Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of physiological
and pathophysiological roles during central nervous system (CNS) development. In …

Determining the effect of gene deletion is a fundamental approach to understanding gene
function. Conventional genetic screens exhibit biases, and genes contributing to a phenotype …

The functions of many open reading frames (ORFs) identified in genome-sequencing projects
are unknown. New, whole-genome approaches are required to systematically determine …

Two large-scale yeast two-hybrid screens were undertaken to identify protein–protein
interactions between full-length open reading frames predicted from the Saccharomyces …

Background CONSORT guidelines call for precise reporting of behavior change interventions:
we need rigorous methods of characterizing active content of interventions with precision …

Increasing population and consumption are placing unprecedented demands on agriculture
and natural resources. Today, approximately a billion people are chronically malnourished …

In interview studies, sample size is often justified by interviewing participants until reaching ‘data
saturation’. However, there is no agreed method of establishing this. We propose …

Without a complete published description of interventions, clinicians and patients cannot
reliably implement interventions that are shown to be useful, and other researchers cannot …