Microfabricated flow cytometers can detect, count, and analyze cells or particles using
microfluidics and electronics to give impedance‐based characterization. Such systems are being …

Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented
by the major histocompatibility complex (pMHC) on the surface of professional antigen-…

MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting
CD8 + T cell immunity remains unknown. Here we report that miRNA-155 is required for …

Protective adaptive immune responses rely on TCR-mediated recognition of Ag-derived
peptides presented by self-MHC molecules. However, self-Ag (tumor)-specific TCRs are often of …

Cytotoxic CD8 T cells mediate immunity to pathogens and they are able to eliminate malignant
cells. Immunity to viruses and bacteria primarily involves CD8 T cells bearing high affinity …

… the n infiltrating TCRs and m non-infiltrating TCRs, we calculate the frequency, F, of HA TCRs
in this entire set of n + m TCRs. Then, for each of the n blood TCRs and m tumor TCRs, we …

Through a rational design approach, we generated a panel of HLA-A*0201/NY-ESO-1 157–165
-specific T cell receptors (TCR) with increasing affinities of up to 150-fold from the wild-…

… Fourth, the average BMI (27 kg/m 2 ) in our study sample was higher than that in the literature,
especially in studies evaluating low-tube-voltage techniques for contrast media volume …

Anti-self/tumor T cell function can be improved by increasing TCR-peptide MHC (pMHC) affinity
within physiological limits, but paradoxically further increases (K d < 1 μM) lead to drastic …

Background Few studies have investigated the impact of obesity on the response to tumor
necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim of our …