Rheumatoid factors: host resistance or autoimmunity?

MM Newkirk - Clinical immunology, 2002 - Elsevier
Rheumatoid factors (RFs), autoantibodies that bind to the Fc portion of IgG, are important in
the immune response. RF-committed B-cells exist in the circulating lymphocyte pool in a high …

[HTML][HTML] Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level

…, Z Hel, D Marion, MC Ruiz, MM Newkirk… - Journal of Biological …, 2005 - ASBMB
… Phage (10 6 ) were plated on XL-1 Blue MRF′ bacterial lawn at 50,000 plaque-forming
units per 150-mm plate. Polyvinylidene difluoride membranes (Millipore) soaked in 10 mm IPTG …

[HTML][HTML] Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis

MM Newkirk, R Goldbach-Mansky, J Lee, J Hoxworth… - Arthritis Res Ther, 2003 - Springer
… The odds ratio for the association between elevated IgG-AGE positive status and erythrocyte
sedimentation rate greater than 50 mm/hour for all 238 patients was 2.45 (95% confidence …

Elevated levels of IgM and IgA antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF)-positive …

MM Newkirk, R Goldbach-Mansky, BW Senior… - …, 2005 - academic.oup.com
Objective. Antibodies to Proteus mirabilis were previously detected in patients with established
rheumatoid arthritis (RA). We examined the prevalence of antibodies to P. mirabilis and …

[HTML][HTML] Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection

MM Newkirk, WJ van Venrooij, GS Marshall - Arthritis Research & Therapy, 2001 - Springer
The induction of autoantibodies to U1 small nuclear ribonucleoprotein (U1 snRNP) complexes
is not well understood. We present evidence that healthy individuals with cytomegalovirus …

Familial clustering of the serum cytokine profile in the relatives of rheumatoid arthritis patients

…, X Li, CN Bernstein, MM Newkirk… - Arthritis & …, 2012 - Wiley Online Library
Objective Rheumatoid arthritis (RA) is prevalent in North American Native populations, with
a high frequency of multicase families and seropositivity in first‐degree relatives. This study …

Differential clearance of glycoforms of IgG in normal and autoimmune‐prone mice

MM Newkirk, J Novick, MM Stevenson… - Clinical & …, 1996 - Wiley Online Library
In order to understand better the origins of the elevated levels of the glycoform of IgG that
lacks galactose on both arms of the oligosaccharide chain (G0%) located in the Fc, which …

Complications of immunosuppression associated with weekly low dose methotrexate.

…, JD Skelton, DG Haegert, MM Newkirk… - The Journal of …, 1991 - europepmc.org
Complications of immunosuppression are thought to be rare with the use of low dose pulse
methotrexate (MTX) for nonneoplastic conditions. We describe 4 complications of …

Distinct bacterial colonization patterns of Escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis

MM Newkirk, A Zbar, M Baron, AR Manges - Rheumatology, 2010 - academic.oup.com
Objectives. The aetiology of RA is unknown; however, bacterial exposure, particularly to
Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae, has been linked to disease …

Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

…, TS Lieu, I Sanz, J Hanke, MM Newkirk… - The Journal of …, 1990 - Am Soc Clin Investig
… The 1.5-mm gels were run at 20 mA constant current on a mini-gel apparatus model SE-200
(Hoefer Scientific Instruments, San Francisco, CA). Protein that had been electrophoresed …