Rheumatoid arthritis (RA) is a chronic, systemic, immune-mediated inflammatory disease
associated with decreased life expectancy and quality of life. RA is characterized by chronic …

Basic research in pattern formation is concerned with the generation of phenotypes and
tissues. It can therefore lead to new tools for medical research. These include phenotypic …

The immunomodulatory effect of the autonomic nervous system has raised considerable
interest over the last decades. Studying the influence on the immune system and the role in …

… Vervoordeldonk and Tak contributed equally to this work. … Vervoordeldonk and Tak
contributed equally to this work. … Vervoordeldonk and Tak contributed equally to this work. …

Mycobacterium tuberculosis bacilli are intracellular organisms that reside in phagosomes of
alveolar macrophages (AMs). To determine the in vivo role of AM depletion in host defense …

Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators
via canonical NF-κB signaling, as well as late expression of the anti-inflammatory enzyme …

Introduction The inflammatory reflex is a physiological mechanism through which the nervous
system maintains immunologic homeostasis by modulating innate and adaptive immunity. …

We investigated the therapeutic potential and mechanism of action of IFN-β protein for the
treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. …

Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans.
Both preclinical and clinical studies showed that antibodies against AAV block transduction …

The efferent vagus nerve can regulate inflammation via its principal neurotransmitter
acetylcholine (ACh), a concept referred to as the 'cholinergic anti-inflammatory pathway'. ACh …