User profiles for M. F. Berger
Michael F BergerMember, Memorial Sloan-Kettering Cancer Center Verified email at mskcc.org Cited by 82531 |
The emerging clinical relevance of genomics in cancer medicine
The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials
…, DT Cheng, P Sabbatini, J Baselga, MF Berger… - Drug discovery today, 2015 - Elsevier
Highlights • Comprehensive precision medicine strategies require a comprehensive
multidisciplinary approach. • Screening assays must be sufficiently broad to identify the full …
multidisciplinary approach. • Screening assays must be sufficiently broad to identify the full …
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
The systematic translation of cancer genomic data into knowledge of tumour biology and
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …
identification of genomic alterations in genes and pathways that can be targeted …
The mutational landscape of head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing …
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
As more clinically relevant cancer genes are identified, comprehensive diagnostic approaches
are needed to match patients to therapies, raising the challenge of optimization and …
are needed to match patients to therapies, raising the challenge of optimization and …
The value of cell‐free DNA for molecular pathology
Over the past decade, advances in molecular biology and genomics techniques have
revolutionized the diagnosis and treatment of cancer. The technological advances in tissue …
revolutionized the diagnosis and treatment of cancer. The technological advances in tissue …
OncoKB: a precision oncology knowledge base
Purpose With prospective clinical sequencing of tumors emerging as a mainstay in cancer
care, an urgent need exists for a clinical support tool that distills the clinical implications …
care, an urgent need exists for a clinical support tool that distills the clinical implications …
[HTML][HTML] Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation …
The identification of specific genetic alterations as key oncogenic drivers and the development
of targeted therapies are together transforming clinical oncology and creating a pressing …
of targeted therapies are together transforming clinical oncology and creating a pressing …