Osteoarthritis is the most common form of arthritis, affecting millions of people in the United
States. It is a complex disease whose etiology bridges biomechanics and biochemistry. …

Osteoarthritis (OA) is the most common joint disorder in the world. In Western populations it
is one of the most frequent causes of pain, loss of function and disability in adults. …

Bones break because the forces applied to them exceed their strength. For most non-spine
fractures, this force results from a fall. Falls generate at least 10 times the energy necessary …

Background Previous studies have shown that alendronate can increase bone mineral
density (BMD) and prevent radiographically defined (morphometric) vertebral fractures. The …

Women with low bone density in the radius or calcaneus are at increased risk of hip fracture.
To see whether bone density of the hip measured by dual X-ray absorptiometry is a better …

Background Many risk factors for hip fractures have been suggested but have not been
evaluated in a comprehensive prospective study. Methods We assessed potential risk factors, …

The assessment of vertebral fracture by conventional radiography has been refined and
improved using either semiquantitative or quantitative criteria. The inter‐ and intraobserver …

Falls are a major threat to the health of older persons. We evaluated potential risk factors for
falls in 325 community-dwelling persons aged 60 years or older who had fallen during the …

We examined the effect of alendronate treatment for 3–4 yr on risk of new fracture among
3658 women with osteoporosis enrolled in the Fracture Intervention Trial. This cohort included …

Background Osteoporotic fractures, including clinically detected vertebral fractures, are
associated with increased mortality. However, only one third of vertebral fractures are diagnosed. …