microRNA (miRNA)-mediated RNA interference has been identified as a novel mechanism
that regulates protein expression at the translational level. Recent publications have …

Using a compound microscope and the blood of several animals (including the elephant!),
the English anatomist, TW Jones, discovered, in 1846, that some white blood cells contained …

Target discovery, which involves the identification and early validation of disease-modifying
targets, is an essential first step in the drug discovery pipeline. Indeed, the drive to determine …

Background Trastuzumab improves survival in the adjuvant treatment of HER-positive
breast cancer, although combined therapy with anthracycline-based regimens has been …

Posttranscriptional regulation of gene expression by microRNAs (miRNAs) has been implicated
in the regulation of chronic physiological and pathological responses. In this report, we …

Cell-penetrating peptides such as antennapedia, TAT, transportan and polyarginine have
been extensively employed for in vitro and in vivo delivery of biologically active peptides. …

Although the immune response is predominantly controlled at the transcriptional level,
microRNA-mediated RNA interference is emerging as an important regulatory mechanism that …

Background At present, nothing is known of the role of miRNAs in the immune response in
vivo despite the fact that inflammation is thought to underlie multiple acute and chronic …

The therapeutic application of siRNA shows promise as an alternative approach to small-molecule
inhibitors for the treatment of human disease. However, the major obstacle to its use …

It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological
responses, and that they do so by a diverse range of mechanisms. In the field of immunology, …