The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup
has increased dramatically in the last hundred years and correlates closely with the rise in …

… (Lanaspa MA, manuscript under review). High-salt diets are independently associated
with metabolic syndrome/diabetes[135], [136] and NAFLD. Thus, it seems likely that both high …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Metabolic syndrome represents a collection of abnormalities that includes fatty liver, and it
currently affects one-third of the United States population and has become a major health …

Background/Aims: Endothelial dysfunction is associated with mitochondrial alterations. We
hypothesized that uric acid (UA), which can induce endothelial dysfunction in vitro and in vivo…

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension, metabolic …

Climate change has led to significant rise of 0.8 C–0.9 C in global mean temperature over the
last century and has been linked with significant increases in the frequency and severity of …

… 90 Ma) to the last common ancestor of apes (∼20 Ma). In support of this conclusion, An19/22
is significantly more catalytically efficient than An26 (P < 0.0001), and An26 is significantly …

Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty
liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to …

The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has
been linked with recurrent dehydration. Here we tested whether recurrent dehydration may …