Nuclear lamins: key regulators of nuclear structure and activities - Prokocimer - 2009 -
Journal of Cellular and Molecular Medicine - Wiley Online Library … Miron Prokocimer…

The nuclear lamina is a structure near the inner nuclear membrane and the peripheral
chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin-…

The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis necessitate
therapeutic improvement. Current advances in AML research yield important insights …

The p53 gene codes for a nuclear protein that has an important role in normal cellular
replication 1–4 . The concentration of p53 protein is frequently elevated in transformed cells 1,2 . …

The human p53 tumor antigen comprises several physically distinct proteins. Two p53
proteins, separable by polyacrylamide gel electrophoresis, are expressed by the human …

… M Prokocimer and V Rotter … of a similar spectrum of cancers in mice transgenic for a mutant
p53 under its own prom ~ ter . ' ~ ~ Several studies have found germline mutations in the p53 …

Loss of normal p53 function was found frequently to interfere with response of cancer cells to
conventional anticancer therapies. Since more than half of all human cancers possess p53 …

Lamins are nuclear intermediate filaments. In addition to their structural roles, they are
implicated in basic nuclear functions such as chromatin organization, DNA replication, …

Molecular structural analysis of the p53 gene in patients with Philadelphia chromosome-positive
chronic myelogenous leukemia (CML) indicates a significant incidence of gene …

… in all patients, and serum b2microglobulin (b2-M) was measured in 81 patients using an …
CA 125, LDH and b2-M levels served as dichotomous variables using the upper normal …