Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

The TNFAIP3 (tumor necrosis factor alpha–induced protein 3) gene encodes a ubiquitin
editing enzyme, A20, that restricts NF-κB–dependent signaling and prevents inflammation. We …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions. …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks. We …

OBJECTIVE: We present the second reported case of autopsy-confirmed chronic traumatic
encephalopathy in a retired professional football player, with neuropathological features that …

Genome-wide association studies (GWAS) have identified several risk variants for late-onset
Alzheimer's disease (LOAD) 1 , 2 . These common variants have replicable but small effects …