Epidemiology, risk factors, and natural history of hepatocellular carcinoma

…, A Terranova, LAM Castagnetta - Annals of the New …, 2002 - Wiley Online Library
The incidence of hepatocellular carcinoma is increasing in many countries. The estimated
number of new cases annually is over 500,000, and the yearly incidence comprises between …

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.

LA Castagnetta, G Carruba, OM Granata… - The Journal of …, 2003 - jrheum.org
OBJECTIVE: It has been proposed that physiologic levels of estrogens stimulate immune
responses whereas androgens suppress inflammatory reactions. Thus, prevalence of synovial …

Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor

LA Castagnetta, MD Miceli, CM Sorci, U Pfeffer… - …, 1995 - academic.oup.com
We report that growth of LNCaP human prostate cancer cells is significantly stimulated (up
to 120% above control) by physiological estradiol (E2) concentrations. This growth increase …

Tissue content of hydroxyestrogens in relation to survival of breast cancer patients

LAM Castagnetta, OM Granata, A Traina… - Clinical cancer …, 2002 - AACR
Purpose: The main goal of our study was to assess estrogen contents of breast tumor tissues,
having different estrogen receptor status, in relation to long-term follow-up of patients. …

Local Estrogen Formation by Nontumoral, Cirrhotic, and Malignant Human Liver Tissues and Cells

LAM Castagnetta, B Agostara, G Montalto, L Polito… - Cancer research, 2003 - AACR
We have investigated the activity and expression of aromatase enzyme in nontumoral,
cirrhotic, and malignant human liver tissues and cells using both chromatographic and reverse …

Gas chromatography/mass spectrometry of catechol estrogens

LA Castagnetta, OM Granata, FP Arcuri, LM Polito… - Steroids, 1992 - Elsevier
Catecholestrogens (CCEs), namely 2- or 4-hydroxyestradiol and hydroxyestrone, are highly
polar, reactive, and extremely labile estrogen metabolites in many experimental conditions. …

Expression of different 17β-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells

LAM Castagnetta, G Carruba, A Traina… - …, 1997 - academic.oup.com
The 17β-hydroxysteroid dehydrogenase (17βHSD) enzyme system governs important redox
reactions at the C17 position of steroid hormones. Different 17βHSD types (no. 1–4) have …

Regulation of cell‐to‐cell communication in non‐tumorigenic and malignant human prostate epithelial cells

…, F Saladino, JE Trosko, LAM Castagnetta - The …, 2002 - Wiley Online Library
BACKGROUND Gap‐junction‐mediated intercellular communication (GJIC) is required for
normal development and tissue homeostasis. However, the role of GJIC in human prostate …

Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer cells

…, C Soci, M Pavone-Macaluso, LAM Castagnetta - Steroids, 1994 - Elsevier
In order to betweer define potential mechanisms of growth regulation in human prostate
cancer cells, we have compared biological responses (such as short-term response to both …

Human prostate cancer: a direct role for oestrogens

LAM Castagnetta, G Carruba - Ciba Foundation Symposium …, 2007 - Wiley Online Library
We have studied the response to oestrogen and expression of oestrogen receptors in responsive
LNCaP and androgen non‐responsive PC3 human prostate cancer cell lines. Growth …