The primary progressive aphasias are a heterogeneous group of focal ‘language-led’
dementias that pose substantial challenges for diagnosis and management. Here we present a …

Importance Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy
(PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult …

Objective We tested the hypothesis that plasma neurofilament light chain (NfL) identifies
asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)–causing mutations …

Impaired processing of emotional signals is a core feature of frontotemporal dementia
syndromes, but the underlying neural mechanisms have proved challenging to characterize and …

Background Reliable biomarkers of frontotemporal dementia (FTD) are currently lacking.
FTD may be associated with chronic immune dysfunction, microglial activation and raised …

If we expose students to a study of human suffering we have a responsibility to guide them
through it. But is this the role of school history? This issue is the rationale behind teaching the …

Background Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative
disorder presenting clinically with personality change (behavioural variant FTD (bvFTD)) or …

Background Studies have previously shown evidence for presymptomatic cortical atrophy in
genetic FTD. Whilst initial investigations have also identified early deep grey matter volume …

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and
encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) …

A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others.
Social cognition problems in FTD include impaired emotion processing and theory of mind …