User profiles for Lucy R Wedderburn

Lucy Wedderburn

UCL GOS Institute of Child health
Verified email at ucl.ac.uk
Cited by 20298

[HTML][HTML] Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

…, A Radziszewska, C Ciurtin, LR Wedderburn… - Nature …, 2020 - nature.com
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, …

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

…, H Peckham, C Ciurtin, LR Wedderburn, R Beale… - Science, 2020 - science.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans.
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected …

CD4+ CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis

IM de Kleer, LR Wedderburn, LS Taams… - The journal of …, 2004 - journals.aai.org
This study investigates the role of CD4+ CD25+ regulatory T cells during the clinical course
of juvenile idiopathic arthritis (JIA). Persistent oligoarticular JIA (pers-OA JIA) is a subtype of …

[PDF][PDF] Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells

…, JJ Manson, I Drozdov, C Bock, LR Wedderburn… - Cell metabolism, 2020 - cell.com
The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived
signals supports the maintenance of tolerance. However, whether microbiota-…

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

…, M Bajaj-Elliott, LR Wedderburn - Proceedings of the …, 2010 - National Acad Sciences
In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of
inflammation. In human arthritis the majority of IL-17–secreting cells within the joint express a …

Interleukin‐17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers

…, H Varsani, P Hunter, LR Wedderburn - … : Official Journal of …, 2008 - Wiley Online Library
Objective To identify interleukin‐17 (IL‐17)–producing T cells from patients with juvenile
idiopathic arthritis (JIA), and investigate their cytokine production, migratory capacity, and …

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

…, EK Wakeland, CA Wallace, LR Wedderburn… - Nature …, 2013 - nature.com
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …

Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study

…, NM Wulffraat, LR Wedderburn… - Annals of the …, 2007 - ard.bmj.com
Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders
with, for the most part, an unknown immunopathogenesis. Although onset and disease …

Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial

D Foell, N Wulffraat, LR Wedderburn, H Wittkowski… - Jama, 2010 - jamanetwork.com
Context Novel therapies have improved the remission rate in chronic inflammatory disorders
including juvenile idiopathic arthritis (JIA). Therefore, strategies of tapering therapy and …

Th17 and regulatory T cells: rebalancing pro-and anti-inflammatory forces in autoimmune arthritis

K Nistala, LR Wedderburn - Rheumatology, 2009 - academic.oup.com
Inflammatory T cells are thought to be central to the pathology of autoimmune arthritis. Th17
cells, CD4 T cells that secrete the pro-inflammatory cytokine IL-17 play a critical role in …