Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
…, Ankylosing Spondylitis: Bradbury Linda A 48 Farrar … - Nature …, 2007 - nature.com
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility
complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), …
complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
…, MM Ward, MH Weisman, C Farrar, LA Bradbury… - Nature …, 2011 - nature.com
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
[HTML][HTML] Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
…, RV Thakker, KA Addison, LA Bradbury… - PLoS …, 2011 - journals.plos.org
Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral
density (BMD) is a major predisposing factor to fracture and is known to be highly heritable…
density (BMD) is a major predisposing factor to fracture and is known to be highly heritable…
Enrichment of circulating interleukin‐17–secreting interleukin‐23 receptor–positive γ/δ T cells in patients with active ankylosing spondylitis
…, SI Davidson, R Duan, LA Bradbury… - Arthritis & …, 2012 - Wiley Online Library
Objective Ankylosing spondylitis (AS) is a common inflammatory arthritis affecting primarily
the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to …
the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to …
[HTML][HTML] Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
…, Ø Førre, J Tuomilehto, K Laiho, LA Bradbury… - Nature …, 2015 - nature.com
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which
HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains …
HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains …
[HTML][HTML] Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease
P Danoy, K Pryce, J Hadler, LA Bradbury, C Farrar… - PLoS …, 2010 - journals.plos.org
Ankylosing spondylitis (AS) is a common inflammatory arthritic condition. Overt inflammatory
bowel disease (IBD) occurs in about 10% of AS patients, and in addition 70% of AS cases …
bowel disease (IBD) occurs in about 10% of AS patients, and in addition 70% of AS cases …
Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis
…, P Leo, P Mukhopadhyay, LA Bradbury… - Arthritis & …, 2015 - Wiley Online Library
Objective To use high‐density genotyping to investigate the genetic associations of acute
anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS). Methods …
anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS). Methods …
[PDF][PDF] The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis
…, AM Crane, AM Sims, HJ Cordell, LA Bradbury… - The American Journal of …, 2004 - cell.com
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy.
Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not …
Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not …
[HTML][HTML] Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis
…, C Wright, G Thomas, LA Bradbury… - Molecular & cellular …, 2012 - ASBMB
Ankylosing Spondylitis (AS) is a common inflammatory rheumatic disease with a predilection
for the axial skeleton, affecting 0.2% of the population. Current diagnostic criteria rely on a …
for the axial skeleton, affecting 0.2% of the population. Current diagnostic criteria rely on a …