Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

ContextConventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of …

Objective Remission in rheumatoid arthritis (RA) is an increasingly attainable goal, but there
is no widely used definition of remission that is stringent but achievable and could be …

ContextIn vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not
COX-1, suggesting that this drug may have anti-inflammatory and analgesic activity without …

Background Lack of standardization of outcome measures limits the usefulness of clinical
trial evidence to inform health care decisions. This can be addressed by agreeing on a …

… Address reprint requests to Lee S. Simon, MD, Division of Rheumatology and Metabolic
Bone Disease: Beth Israel Deaconess Medical Center, Lowry Medical Office Building, Suite 5A, …

Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase (COX)
and subsequent downstream synthetases. Recently, it has been found that there are two …

Background The antiinflammatory, analgesic, and antipyretic actions of aspirin became well
known during the years after its introduction. More recently, the beneficial effects of the …

Objective Bisphosphonates have slowed the progression of osteoarthritis (OA) in animal
models and have decreased pain in states of high bone turnover. The Knee OA Structural …

This review focuses on three preserved, ancient, biological mechanisms (physical activity,
insulin sensitivity, and fat storage). Genes in humans and rodents were selected in an …