Atypical hemolytic uremic syndrome (aHUS) is a rare, possibly life-threatening disease
characterized by platelet activation, hemolysis and thrombotic microangiopathy (TMA) leading to …

The therapeutic approach to childhood nephrotic syndrome is based on a series of studies
that began with an international collaborative effort sponsored by the International Study of …

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter
collaborative consortium established to develop a translational research infrastructure for …

Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway
dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ …

Background Few studies have prospectively evaluated the progression of chronic kidney
disease (CKD) in children and adolescents, as well as factors associated with progression. …

Background Children admitted to the hospital with urinary tract infections (UTIs) receive
empirical antibiotic therapy. There is limited information on bacterial resistance to commonly …

There are 4 classic features of nephrotic syndrome (Box 1). 1 There are many different causes
of nephrotic syndrome (Table 1), but they share a common pathophysiology: massive loss …

Background and objectives: Children with chronic kidney disease (CKD) have an increased
risk of progression to ESRD. There is a need to identify treatments to slow the progression of …

Steroid-sensitive nephrotic syndrome (SSNS) accounts for> 80% of cases of nephrotic
syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. …

Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The
Global aHUS Registry collects real-world data on the natural history of the disease. Here we …