Backround and aims: The aetiopathogenesis of Crohn’s disease, an inflammatory bowel
disease (IBD), is not yet fully understood. Autoimmune mechanisms are thought to play a role in …

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which platelets are
opsonised by autoantibodies and destroyed by macrophages. Therefore, ITP represents a …

Introduction Interstitial lung disease (ILD) is a frequent manifestation of systemic sclerosis (SSc),
and cytokines can contribute to the disease pathology. The aim of the current study was …

Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however, …

The expression of oncofetal H19 RNA and its localization/cellular source was analyzed in
synovial tissue (ST) and isolated synovial macrophages (Mϕ) or synovial fibroblasts (SFBs) by …

Objective. Sjögren’s syndrome (SS) is character-ized by autoimmune infiltration and focal
accumulation of lymphocytes in the exocrine glands, with a predominance of CD4-positive T …

Although the immunopathogenesis of rheumatoid arthritis (RA) remains unclear, recent
advances have paved the way for new therapies, such as anti-cytokine and cell-directed …

The purpose of preclinical research is to inform the development of novel diagnostics or
therapeutics, and the results of experiments on animal models of disease often inform the …

The effect of splenectomy on circulating memory B cells in autoimmune thrombocytopenia
purpura (AITP) patients has not yet been addressed. We therefore analyzed the distribution …

Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive
mediators via posttranslational carbamylation of proteins. As a new consequence of …