Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes

…, SW Li, LY Wong, SWL Lee, S Tam, EWK Wong… - Atherosclerosis, 2013 - Elsevier
BACKGROUND: Suboptimal vitamin D status is associated with endothelial dysfunction and
an increased risk of cardiovascular diseases but it is unclear whether vitamin D …

Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes

…, LY Wong, SWL Lee, S Tam, EWK Wong… - The Journal of …, 2011 - academic.oup.com
Context: Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and
endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial …

[HTML][HTML] Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells

…, JCY Ho, WH Lai, YC Chan, KM Ng, LY Wong… - Aging (Albany …, 2012 - ncbi.nlm.nih.gov
AIMS We identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the
lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated …

Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway

…, WH Lai, KW Au, CYJ Ho, LY Wong… - Molecular …, 2010 - academic.oup.com
Embryonic stem cells (ESCs) can differentiate into functional cardiomyocytes and thus represent
a promising cell source for cardiac regenerative therapy. Nevertheless, the therapeutic …

[HTML][HTML] Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

…, RM Porsch, L Sun, W Xu, H Zheng, LY Wong… - Nature …, 2015 - nature.com
Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform
an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina …

Modeling treatment response for lamin A/C related dilated cardiomyopathy in human induced pluripotent stem cells

YK Lee, YM Lau, ZJ Cai, WH Lai, LY Wong… - Journal of the …, 2017 - Am Heart Assoc
Background Precision medicine is an emerging approach to disease treatment and prevention
that takes into account individual variability in the environment, lifestyle, and genetic …

[HTML][HTML] Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells

WH Lai, JCY Ho, YC Chan, JHL Ng, KW Au, LY Wong… - PloS one, 2013 - journals.plos.org
Functional endothelial-like cells (EC) have been successfully derived from different cell
sources and potentially used for treatment of cardiovascular diseases; however, their relative …

Amelioration of X-linked related autophagy failure in Danon disease with DNA methylation inhibitor

…, SW Choi, YK Lee, WH Lai, KW Au, YM Lau, LY Wong… - Circulation, 2016 - Am Heart Assoc
Background: Danon disease is an X-linked disorder that leads to fatal cardiomyopathy caused
by a deficiency in lysosome-associated membrane protein-2 (LAMP2). In female patients, …

Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification

…, PL Khong, CP Lau, WH Lai, LY Wong… - The Journal of …, 2010 - jrheum.org
Objective. Patients with rheumatoid arthritis (RA) are prone to premature atherosclerosis.
We hypothesize that depletion of circulating endothelial progenitor cells (EPC) related to RA …

[PDF][PDF] Generation of human liver chimeric mice with hepatocytes from familial hypercholesterolemia induced pluripotent stem cells

J Yang, Y Wang, T Zhou, LY Wong, XY Tian, X Hong… - Stem cell reports, 2017 - cell.com
Familial hypercholesterolemia (FH) causes elevation of low-density lipoprotein cholesterol (LDL-C)
in blood and carries an increased risk of early-onset cardiovascular disease. A …