MBL2, FCN1, FCN2 and FCN3—the genes behind the initiation of the lectin pathway of complement

P Garred, C Honoré, YJ Ma, L Munthe-Fog… - Molecular …, 2009 - Elsevier
Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are
soluble collagen-like proteins that are involved in innate immune defence. They bind sugar …

The Impact of FCN2 Polymorphisms and Haplotypes on the Ficolin‐2 Serum Levels

L MuntheFog, T Hummelshøj… - Scandinavian …, 2007 - Wiley Online Library
Ficolin‐2 (L‐ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition
molecule found in human serum in which inter‐individual variation in serum appears to be …

[HTML][HTML] Immunodeficiency Associated with FCN3 Mutation and Ficolin-3 Deficiency

L Munthe-Fog, T Hummelshøj, C Honoré… - … England Journal of …, 2009 - Mass Medical Soc
<p id="p001">Ficolin-3, encoded by the <italic>FCN3</italic> gene and expressed in the
lung and liver, is a recognition molecule in the lectin pathway of the complement system. …

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2

T Hummelshoj, L Munthe-Fog… - Human molecular …, 2005 - academic.oup.com
The ficolin 1, 2 and 3 (derived from the FCN1, 2 and 3 genes, respectively) are homologous
soluble pattern recognition molecules of importance for innate immunity, comprising collagen…

Mesenchymal stem cell therapy of acute thermal burns: a systematic review of the effect on inflammation and wound healing

…, BS Rasmussen, E Haastrup, L Munthe-Fog… - Burns, 2021 - Elsevier
Aim Mesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote
tissue repair, and may extend their utility to burn care. This comprehensive review of the …

[HTML][HTML] The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in …

H Kozarcanin, C Lood, L MuntheFog… - Journal of Thrombosis …, 2016 - Elsevier
L. MuntheFog and MO Skjoedt participated in the preparation of the antibodies used in this
work as well as critical revision of the work. OA Hamad participated in analysis of the data as …

Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state

L Munthe-Fog, T Hummelshøj, YJ Ma, BE Hansen… - Molecular …, 2008 - Elsevier
Ficolin-3 (Hakata antigen or H-ficolin) is a soluble pattern recognition molecule in the lectin
complement pathway. We speculated whether common genetic variations in the FCN3 gene …

[HTML][HTML] Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome

S Bastrup-Birk, MO Skjoedt, L Munthe-Fog, JJ Strom… - PLoS …, 2013 - journals.plos.org
The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune
system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 …

Soluble collectin-12 (CL-12) is a pattern recognition molecule initiating complement activation via the alternative pathway

YJ Ma, E Hein, L Munthe-Fog, MO Skjoedt… - The Journal of …, 2015 - journals.aai.org
Soluble defense collagens including the collectins play important roles in innate immunity.
Recently, a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has …

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation

L Munthe-Fog, T Hummelshoj, C Honoré, ME Moller… - Genes & …, 2012 - nature.com
Ficolin-1 is a recognition molecule of the lectin complement pathway. The ficolin-1 gene
FCN1 is polymorphic, but the functional and clinical consequences are unknown. The …