Topotecan–a novel topoisomerase I inhibitor: pharmacology and clinical experience

C Kollmannsberger, K Mross, A Jakob, L Kanz… - Oncology, 1999 - karger.com
Topotecan, a water-soluble analogue of camptothecin, is a newly available cytotoxic agent
which acts as an inhibitor of topoisomerase I, an enzyme necessary for DNA replication. …

Platinum organ toxicity and possible prevention in patients with testicular cancer

…, C Kollmannsberger, L Kanz… - … journal of cancer, 1999 - Wiley Online Library
Advances in the management of metastatic testicular cancer are attributed mainly to the
introduction of cisplatin into combination chemotherapy. In parallel with the development of …

Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature

…, C Richter, A Engel, I Günaydin, L Kanz - Seminars in arthritis and …, 2007 - Elsevier
OBJECTIVE: To determine the efficacy of the interleukin (IL)-1-receptor antagonist (IL-1RA)
anakinra in patients with adult-onset Still’s disease (AOSD) refractory to standard treatments …

Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells

…, G Stuhler, VL Reichardt, L Kanz… - Blood, The Journal …, 2000 - ashpublications.org
Vaccination of patients with cancer using dendritic cells (DCs) was shown to be effective for
B-cell lymphoma and malignant melanoma. Here we provide evidence that patients with …

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

…, V Becker, AJ Gross, B Hemmerlein, L Kanz… - Nature medicine, 2000 - nature.com
Reports of spontaneous regressions of metastases and the demonstration of tumor-reactive
cytotoxic T lymphocytes indicate the importance of the host's immune system in controlling …

High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial

E Thiel, A Korfel, P Martus, L Kanz, F Griesinger… - The lancet …, 2010 - thelancet.com
Background High-dose methotrexate is the standard of care for patients with newly diagnosed
primary CNS lymphoma. The role of whole brain radiotherapy is controversial because …

Infusion of cytomegalovirus (CMV)–specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy

…, A Moris, HG Rammensee, L Kanz… - Blood, The Journal …, 2002 - ashpublications.org
We adoptively transferred donor-derived cytomegalovirus (CMV)-specific T-cell lines into 8
stem cell transplant recipients lacking CMV-specific T-cell proliferation. All patients, of whom …

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by …

…, S Rafii, MAS Moore, W Brugger, L Kanz - Blood, The Journal …, 1998 - ashpublications.org
The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 (fusin, LESTR)
are likely to be involved in the trafficking of hematopoietic progenitor and stem cells, as …

[HTML][HTML] Treatment of older patients with mantle-cell lymphoma

…, R Forstpointner, H Tilly, L Kanz… - … England Journal of …, 2012 - Mass Medical Soc
Background The long-term prognosis for older patients with mantle-cell lymphoma is poor.
Chemoimmunotherapy results in low rates of complete remission, and most patients have a …

Detection and identification of fungal pathogens in blood by using molecular probes

…, J Van Burik, D Engelhard, L Kanz… - Journal of Clinical …, 1997 - Am Soc Microbiol
… Samples were then diluted to a final concentration of 50 ng/l. Moreover, cell … in 40 l of H2O.
After spectral photometry, the samples were then diluted to a final concentration of 50 ng/l. …