User profiles for L. KLARESKOG

lars klareskog

professor in rheumatology Karolinska Institutet
Verified email at ki.se
Cited by 93087

Tumor necrosis factor antagonist mechanisms of action: a comprehensive review

D Tracey, L Klareskog, EH Sasso, JG Salfeld… - Pharmacology & …, 2008 - Elsevier
During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases

…, I Lundberg, L Klareskog, L Alfredsson - Annals of the …, 2003 - ard.bmj.com
Objective: To quantify the influence of cigarette smoking on the risk of developing rheumatoid
arthritis (RA). Methods: 679 cases and 847 controls included during May 1996–June 2000 …

Immunity to citrullinated proteins in rheumatoid arthritis

L Klareskog, J Rönnelid, K Lundberg… - Annu. Rev …, 2008 - annualreviews.org
Klareskog, and A. Catrina, submitted for publication). … Silica dust and mineral oil exposure
have both been linked to an increased risk for ACPA-positive RA (L. Klareskog, J. Rönnelid, K. …

Genetics of rheumatoid arthritis contributes to biology and drug discovery

…, SC Bae, J Worthington, L Padyukov, L Klareskog… - Nature, 2014 - nature.com
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by …

L Klareskog, P Stolt, K Lundberg… - … : Official Journal of …, 2006 - Wiley Online Library
A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared
epitope)–restricted immune reactions to autoantigens modified by citrullination - Klareskog - …

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind …

L Klareskog, D van der Heijde, JP de Jager, A Gough… - The Lancet, 2004 - thelancet.com
L Klareskog and D van der Heijde had main responsibility for writing the article, with input
from all other authors. L Klareskog provided the clinical variables to be assessed and had …

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

…, KA Siminovitch, PK Gregersen, L Klareskog… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

[HTML][HTML] STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

…, L Padyukov, L Alfredsson, L Klareskog… - … England Journal of …, 2007 - Mass Medical Soc
Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic
component. Susceptibility to disease has been linked with a region on chromosome 2q. …

[HTML][HTML] TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

…, MF Seldin, DL Kastner, L Klareskog… - … England Journal of …, 2007 - Mass Medical Soc
Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

…, A Scheynius, J Kere, L Alfredsson, L Klareskog… - Nature …, 2013 - nature.com
Epigenetic mechanisms integrate genetic and environmental causes of disease, but
comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated …