… Lidia Ibba-Manneschi… Lidia Ibba-Manneschi … Lidia Ibba-Manneschi …

In recent years several studies investigated the role of T lymphocyte subpopulations in the
pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, …

Vascular disease is a hallmark of systemic sclerosis (SSc). It is present in every patient,
being responsible both for the earliest clinical manifestations and the major life-threatening …

Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly
by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a …

Rationale: Systemic sclerosis (SSc) is characterized by widespread microangiopathy,
fibrosis, and autoimmunity. Despite the lack of angiogenesis, the expression of vascular …

Telocytes ( TC ), a cell population located in the connective tissue of many organs of humans
and laboratory mammals, are characterized by a small cell body and extremely long and …

… (J–L) Telocytes do not display immunoreactivity for CD90/Thy-1, while fibroblasts are CD90-…
A CD90-positive vascular wall-resident stem cell niche is scarcely surrounded by telocytes (L…

Background Early endothelial cell (EC) activation/damage and profibrotic Th2-associated
cytokines play a pivotal role in systemic sclerosis (SSc). Interleukin 33 (IL33) is a novel …

Background: Mesenchymal stem cells can differentiate into endothelial cells and participate
in angiogenesis in adults. In experimental models of acute myocardial infarction, …

Crohn's disease ( CD ) is a relapsing chronic inflammatory disorder that may involve all the
gastrointestinal tract with a prevalence of terminal ileum. Intestinal lesions have a …