Background Cardiovascular risk is increased in patients with gout. We compared cardiovascular
outcomes associated with febuxostat, a nonpurine xanthine oxidase inhibitor, with those …

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought
to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of …

Inflammatory phenotypes are recognised in stable adult asthma, but are less well established
in childhood and acute asthma. Additionally, Chlamydophila pneumoniae infection as a …

Background: The association between hyperuricemia, gout, and impaired renal function has
long been recognized. Recent data provide evidence for the causal relationship between …

Objective Renal impairment is a risk factor for gout and a barrier to optimal gout management.
We undertook this exploratory study to obtain data that have been heretofore limited …

… Gunawardhana in the design and conduct of the trial, and participated in data reporting.
Takeda provided writing and editorial assistance (performed by Liqing Xiao, PhD, and Meryl …

Results Of 99 enrolled participants, 86 participants completed the study. Febuxostat led to
significantly greater reduction in 24-hour urinary uric acid (− 58.6%) than either allopurinol (− …

Epigenetic changes including DNA methylation caused by environmental exposures may
contribute to the heterogeneous inflammatory response in asthma. Here we investigate …

Background Asthma is a complex disease that involves both genetic factors and environmental
exposures. Aberrant epigenetic modifications, such as DNA methylation, may be …

Background: Hyperuricemia can accelerate renal decline associated with aging. Chronic
kidney disease is frequently seen in patients with hyperuricemia and gout. Objectives: Assess …