User profiles for L. Bossini-Castillo

Lara Bossini-Castillo

Associate Professor. Department of Genetics, University of Granada, Spain.
Verified email at ugr.es
Cited by 2710

Immunogenetics of systemic sclerosis: defining heritability, functional variants and shared-autoimmunity pathways

L Bossini-Castillo, E López-Isac, J Martín - Journal of autoimmunity, 2015 - Elsevier
… IL12RB2 is located nearby IL23R; however, Bossini-Castillo et al. reported that the
observed signal was independent from IL23R [78]. In regard with IL12RB1, López-Isac et al. …

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

…, AM Erzurumluoglu, B Noyvert, L Bossini-Castillo… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …

Genetics of systemic sclerosis

L Bossini-Castillo, E López-Isac, MD Mayes… - Seminars in …, 2015 - Springer
… The association of three highly linked SNPs in TNIP1 (rs2233287, rs4958881, and rs3792783)
as SSc risk factors was independently replicated by Bossini-Castillo et al., and this locus …

[PDF][PDF] Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

MD Mayes, L Bossini-Castillo, O Gorlova… - The American Journal of …, 2014 - cell.com
… The l for the discovery sets was estimated at 1.07 (US) and 1.085 (Spain). It has been
demonstrated that l increases with sample size.Therefore, it is informative to calculate a rescaled l

[PDF][PDF] A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility

…, JC Taylor, A Vaglio, S Eyre, L Bossini-Castillo… - The American Journal of …, 2015 - cell.com
We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and …

[HTML][HTML] Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

…, L Bossini-Castillo, J Kaplanis, L Ramirez-Navarro… - Nature …, 2022 - nature.com
During activation, T cells undergo extensive gene expression changes that shape the
properties of cells to exert their effector function. Understanding the regulation of this process …

Gene expression variability across cells and species shapes innate immunity

…, JE Park, V Proserpio, G Donati, L Bossini-Castillo… - Nature, 2018 - nature.com
As the first line of defence against pathogens, cells mount an innate immune response,
which varies widely from cell to cell. The response must be potent but carefully controlled to …

[HTML][HTML] GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

…, I Castellvi, L Bossini-Castillo… - Nature …, 2019 - nature.com
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality
rates among rheumatic diseases. We perform a large genome-wide association study (GWAS…

Unraveling the genetic component of systemic sclerosis

JE Martín, L Bossini-Castillo, J Martín - Human genetics, 2012 - Springer
Bossini-Castillo et al. 2011b). The role of the four polymorphisms with the whole disease and
the effects of the associations were consistent (Bossini-Castillo … reported (Bossini-Castillo et …

A rare polymorphism in the gene for Toll‐like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

JCA Broen, L BossiniCastillo, L Van Bon… - Arthritis & …, 2012 - Wiley Online Library
Objective To investigate whether polymorphisms in Toll‐like receptor (TLR) genes, previously
reported to be associated with immune‐mediated diseases, are involved in systemic …