Antiphospholipid syndrome is an autoimmune systemic disorder characterized by arterial,
venous, or small vessel thrombosis and/or recurrent early pregnancy loss, fetal loss, or …

Menopause represents a time of significant clinical and hormonal change. Given the incompletely
understood interrelationship between gonadal hormones and the immune system, it is …

Background Oral contraceptives are rarely prescribed for women with systemic lupus
erythematosus, because of concern about potential negative side effects. In this double-blind, …

Corticosteroids play a central role in the treatment of systemic lupus erythematosus (SLE), a
complex autoimmune disease with multiorgan involvement. Corticosteroids were trialed in …

… Sammaritano,1 Bonnie L. Bermas,2 Eliza E. Chakravarty,3 Christina Chambers,4 Megan …
Sammaritano had full access to all of the data in the study and takes responsibility for the …

Circulating antiphospholipid antibodies (aPL) are associated with a syndrome of thrombosis,
recurrent fetal loss, and thrombocytopenia. We have demonstrated the activation of …

Objective To test the Sapporo criteria for the classification of the antiphospholipid syndrome
(APS). Methods We classified 243 consecutive patients who had clinical diagnoses of …

… Fixing the false-positive rate at 5%, sensitivity improves from 36% with the baseline model
to 50% with addition of sFlt1; positive LR increases from 7.2-10.0 and negative LR decreases …

OBJECTIVES: Systemic lupus erythematosus and antiphospholipid antibody, often identified
in patients with systemic lupus erythematosus, are associated with poor pregnancy outcome…

Objective Studies in mouse models implicate complement activation as a causative factor in
adverse pregnancy outcomes (APOs). We investigated whether activation of complement …