User profiles for L. L. Santos

Leandro L. Santos

- Verified email at incyte.com - Cited by 201

Lucas Lisboa dos Santos

- Verified email at firjan.com.br - Cited by 61

[HTML][HTML] Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks

…, M Relvas-Santos, R Azevedo, LL Santos… - Frontiers in …, 2019 - frontiersin.org
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review

…, M Neves, N Sousa, A Lima, LL Santos - Journal of controlled …, 2015 - Elsevier
Bladder cancer is the most common malignancy of the urinary tract, presents the highest
recurrence rate among solid tumors and is the second leading cause of death in genitourinary …

Mechanisms of cisplatin resistance and targeting of cancer stem cells: adding glycosylation to the equation

…, C Gaiteiro, CA Reis, YG Assaraf, LL Santos - Drug Resistance …, 2016 - Elsevier
Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens …

[HTML][HTML] Frequency of TERT promoter mutations in human cancers

…, L Castro, F Pardal, JM Lopes, LL Santos… - Nature …, 2013 - nature.com
Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying
mechanisms remain poorly understood. Here we report the presence of recurrent somatic …

Influence of proximity to an urban center in the pattern of contamination by marine debris

AS Leite, LL Santos, Y Costa, V Hatje - Marine pollution bulletin, 2014 - Elsevier
In order to test the relationship between the occurrence of marine debris and the distance
from urban areas, nine beaches in the metropolitan area of Salvador, Bahia, Brazil and the …

[HTML][HTML] Bias and unfairness in machine learning models: a systematic review on datasets, tools, fairness metrics, and identification and mitigation methods

…, GOR Cruz, MM Araujo, LL Santos… - Big data and cognitive …, 2023 - mdpi.com
One of the difficulties of artificial intelligence is to ensure that model decisions are fair and
free of bias. In research, datasets, metrics, techniques, and tools are applied to detect and …

Macrophage migration inhibitory factor: a key cytokine in RA, SLE and atherosclerosis

LL Santos, EF Morand - Clinica chimica acta, 2009 - Elsevier
Originally discovered and named as an in vitro inhibitor of macrophage migration, the cytokine
macrophage migration inhibitory factor (MIF) has now been shown to be a key regulator …

Janus kinase 1 inhibitor INCB054707 for patients with moderate‐to‐severe hidradenitis suppurativa: results from two phase II studies

A Alavi, I Hamzavi, K Brown, LL Santos… - British Journal of …, 2022 - academic.oup.com
Background Janus kinase (JAK)‐mediated cytokine signalling contributes to local and
systemic inflammation in hidradenitis suppurativa (HS). Objectives To describe the safety and …

Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice

…, J Yamana, KM O'Sullivan, LL Santos… - The Journal of …, 2006 - journals.aai.org
Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disease of unknown
etiology. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is …

[HTML][HTML] Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells

…, F Calais, H Quinto, C Pen, D Ligeiro, LL Santos… - Molecular …, 2014 - Elsevier
Despite the wide acceptance that glycans are centrally implicated in immunity, exactly how
they contribute to the tilt immune response remains poorly defined. In this study, we sought to …