[HTML][HTML] Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
…, MS Gersch, S Benner, LG Sánchez-Lozada - The American journal of …, 2007 - Elsevier
Currently, we are experiencing an epidemic of cardiorenal disease characterized by
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …
Uric acid and chronic kidney disease: which is chasing which?
…, D Jalal, LG Sánchez-Lozada… - Nephrology Dialysis …, 2013 - academic.oup.com
Serum uric acid is commonly elevated in subjects with chronic kidney disease (CKD), but was
historically viewed as an issue of limited interest. Recently, uric acid has been resurrected …
historically viewed as an issue of limited interest. Recently, uric acid has been resurrected …
Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial …
MA Yu, LG Sánchez-Lozada, RJ Johnson… - Journal of …, 2010 - journals.lww.com
Aims Oxidative stress is known to be a major mechanism of endothelial dysfunction, which
plays a key role in the development of cardiovascular disease. Although uric acid is one of the …
plays a key role in the development of cardiovascular disease. Although uric acid is one of the …
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
LG Sánchez-Lozada, E Tapia… - … of physiology-renal …, 2007 - journals.physiology.org
Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn,
the metabolic syndrome has been epidemiologically linked with renal progression. The …
the metabolic syndrome has been epidemiologically linked with renal progression. The …
Mild hyperuricemia induces glomerular hypertension in normal rats
LG Sánchez-Lozada, E Tapia… - American Journal …, 2002 - journals.physiology.org
Mildly hyperuricemic rats develop renin-dependent hypertension and interstitial renal disease.
Hyperuricemia might also induce changes in glomerular hemodynamics. Micropuncture …
Hyperuricemia might also induce changes in glomerular hemodynamics. Micropuncture …
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia
Endothelial dysfunction is a characteristic feature during the renal damage induced by mild
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response
Background: Excessive fructose intake causes metabolic syndrome in animals and can be
partially prevented by lowering the uric acid level. We tested the hypothesis that fructose …
partially prevented by lowering the uric acid level. We tested the hypothesis that fructose …
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
…, W Mu, C Roncal, LG Sánchez-Lozada… - Journal of the …, 2005 - journals.lww.com
Hypertension and hypertension-associated ESRD are epidemic in society. The mechanisms
responsible for renal progression in mild to moderate hypertension and those groups most …
responsible for renal progression in mild to moderate hypertension and those groups most …
Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy
…, C Wesseling, LG Sánchez-Lozada… - Clinical Journal of the …, 2016 - journals.lww.com
Climate change has led to significant rise of 0.8 C–0.9 C in global mean temperature over the
last century and has been linked with significant increases in the frequency and severity of …
last century and has been linked with significant increases in the frequency and severity of …
[PDF][PDF] High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
…, W Sato, S Maruyama, LG Sánchez‐Lozada… - …, 2013 - Wiley Online Library
Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty
liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to …
liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to …