Objectives There is an important need to evaluate therapeutic approaches for osteoarthritis (OA)
in terms of cost-effectiveness as well as efficacy. Methods The ESCEO expert working …

Importance Even though osteoarthritis is a chronic and progressive disease, pharmacological
agents are mainly studied over short-term periods, resulting in unclear recommendations …

This article reviews the literature related to the absorption, distribution, metabolism and
excretion (ADME) of glucosamine (Gl) in man and in animals after administration of crystalline …

… LC Rovati and G Giacovelli helped design the study and analyse the data. JE Darce had
previously developed the radiograph digital image analaysis system used for the primary …

Background Conventional symptomatic treatments for osteoarthritis do not favorably affect
disease progression. The aim of this randomized, placebo-controlled trial was to determine …

… Giacovelli G, Rovati LC. Clinical efficacy of glucosamine sulfate in osteoarthritis of the spine.
… Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in …

Glucosamine sulfate is a drug used for the treatment of osteoarthritis (OA), based on its
pharmacological and metabolic activities on the cartilage and chondrocytes, complemented by …

OBJECTIVE: To assess the incidence of Total Joint Replacement (TJR) during the long-term
follow-up of patients with knee osteoarthritis (OA) formerly receiving treatment with …

OBJECTIVE: Pharmacokinetic data on glucosamine are scant, limiting the understanding of
glucosamine sulfate mechanism of action in support of its treatment effects in osteoarthritis. …

Objectives Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases
that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess …