[HTML][HTML] Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
…, T Taniguchi, K Fujiu, I Manabe, K Nakamura… - Nature …, 2014 - nature.com
Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation.
So far, a unifying hypothesis underpinning these pathological events remains unknown. …
So far, a unifying hypothesis underpinning these pathological events remains unknown. …
[HTML][HTML] Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis
K Nakamura, AM O'Neill, MR Williams, L Cau… - Scientific reports, 2020 - nature.com
Biofilm formation by bacterial pathogens is associated with numerous human diseases and
can confer resistance to both antibiotics and host defenses. Many strains of Staphylococcus …
can confer resistance to both antibiotics and host defenses. Many strains of Staphylococcus …
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: possible roles in scleroderma
…, K Sugawara, T Yamashita, K Nakamura… - Journal of Experimental …, 2017 - rupress.org
Systemic sclerosis (SSc), or scleroderma, is a multisystem autoimmune disorder characterized
by vasculopathy and fibrosis in the skin and internal organs, most frequently in the …
by vasculopathy and fibrosis in the skin and internal organs, most frequently in the …
Contribution of soluble forms of programmed death 1 and programmed death ligand 2 to disease severity and progression in systemic sclerosis
…, A Yoshizaki, S Ebata, K Nakamura… - Arthritis & …, 2017 - Wiley Online Library
Objective To determine the function and serum levels of soluble forms of programmed death
1 (sPD‐1) and one of its ligands, soluble PD ligand 2 (sPD‐L2), in patients with systemic …
1 (sPD‐1) and one of its ligands, soluble PD ligand 2 (sPD‐L2), in patients with systemic …
CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic …
…, S Toyama, T Yamashita, K Nakamura… - Experimental …, 2018 - Wiley Online Library
CXCL13, a chemokine for B cells, follicular T cells, T helper 17 cells, and regulatory T cells,
is reported to contribute to the development of systemic sclerosis (SSc), reflecting aberrant …
is reported to contribute to the development of systemic sclerosis (SSc), reflecting aberrant …
Association of anti‐RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis
R Saigusa, Y Asano, K Nakamura… - The Journal of …, 2015 - Wiley Online Library
Patients with systemic sclerosis ( SS c) have an increased risk of malignancy compared with
the general population. Recently, SS c patients with anti‐ RNA polymerase III antibody have …
the general population. Recently, SS c patients with anti‐ RNA polymerase III antibody have …
[HTML][HTML] Glycyrrhizin ameliorates fibrosis, vasculopathy, and inflammation in animal models of systemic sclerosis
T Yamashita, Y Asano, T Taniguchi, K Nakamura… - Journal of Investigative …, 2017 - Elsevier
Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in
extensive tissue fibrosis. Glycyrrhizin, clinically used for chronic hepatic diseases and itching …
extensive tissue fibrosis. Glycyrrhizin, clinically used for chronic hepatic diseases and itching …
Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis
…, T Yamashita, R Saigusa, K Nakamura… - …, 2015 - academic.oup.com
Objectives. Chemerin is a member of adipocytokines with a chemoattractant effect on
plasmacytoid dendritic cells and macrophages and pro-angiogenic properties. We investigated the …
plasmacytoid dendritic cells and macrophages and pro-angiogenic properties. We investigated the …
Charge-dependent anisotropic flow in high-energy heavy-ion collisions from a relativistic resistive magneto-hydrodynamic expansion
K Nakamura, T Miyoshi, C Nonaka, HR Takahashi - Physical Review C, 2023 - APS
We have investigated the charge-dependent anisotropic flow in high-energy heavy-ion
collisions, using relativistic resistive magneto-hydrodynamics (RRMHD). We consider the optical …
collisions, using relativistic resistive magneto-hydrodynamics (RRMHD). We consider the optical …
[HTML][HTML] Systemic sclerosis dermal fibroblasts suppress Th1 cytokine production via galectin-9 overproduction due to Fli1 deficiency
R Saigusa, Y Asano, K Nakamura… - Journal of Investigative …, 2017 - Elsevier
Dermal fibroblasts promote skin-localized transdifferentiation of regulatory T cells to T helper
(Th) type 2-like cells in systemic sclerosis (SSc). However, the entire effect of SSc dermal …
(Th) type 2-like cells in systemic sclerosis (SSc). However, the entire effect of SSc dermal …