Small, soluble metabolites not only are essential intermediates in intracellular biochemical
processes, but can also influence neighbouring cells when released into the extracellular …

Objective Interstitial lung disease ( ILD ) accompanied by anti–melanoma differentiation–associated
gene 5 (anti– MDA ‐5)–positive dermatomyositis ( DM ) is often rapidly progressive …

Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although
previous studies have revealed that HLA-B ∗ 52:01 has an effect on TAK susceptibility, no …

Objectives Rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis often
accompanies anti-melanoma differentiation-associated gene 5 (MDA5)-positive DM. …

Objective To evaluate the efficacy and safety of tocilizumab, an interleukin-6 receptor
antibody, in patients with adult-onset Still’s disease. Methods In this double-blind, randomised, …

Follistatin‐related protein (FRP)/follistatin‐like 1 (FSTL1) is a member of the follistatin protein
family, all of which share a characteristic structure unit found in follistatin, called the FS …

Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature
especially with TGF-β superfamily proteins, and thereby modulates organ development. …

Interstitial lung disease (ILD) is a common complication and sometimes a prognostic factor
of connective tissue diseases (CTDs) in humans. However, suitable animal model of severe …

Objective Hypoxia occurs in tumors, infections, and sites of inflammation, such as in the affected
joints of patients with rheumatoid arthritis (RA). It alleviates inflammatory responses and …

Aim Age at disease onset has been implicated as an indicator of disease activity and severity
in rheumatoid arthritis (RA). This study aimed to investigate how old age at disease onset …