Immunization to multiple defined tumor antigens for specific immune therapy of human cancer
has thus far proven difficult. Eighteen HLA A*0201 + patients with metastatic melanoma …

The analysis of patient blood transcriptional profiles offers a means to investigate the
immunological mechanisms relevant to human diseases on a genome-wide scale. In addition, such …

Each infectious agent represents a unique combination of pathogen-associated molecular
patterns that interact with specific pattern-recognition receptors expressed on immune cells. …

We find that CD11c + cells with many markers of dendritic cells (DCs) are a major cell type in
the skin lesions of psoriasis. These CD11c + cells, which are evident in both epidermis and …

Drugs abused by humans are thought to activate areas in the ventral striatum of the brain
that engage the organism in important adaptive behaviors, such as eating. In support of this, …

About one month after the COVID-19 epidemic peaked in Mainland China and SARS-CoV-2
migrated to Europe and then the US, the epidemiological data begin to provide important …

Psoriasis vulgaris, a skin disease that is considered to be the result of a type 1 autoimmune
response, provides an opportunity for studying the changes that occur in a target-diseased …

Therapeutic modulation of psoriasis with targeted immunosuppressive agents defines
inflammatory genes associated with disease activity and may be extrapolated to a wide range of …

Background Leukocyte function–associated antigen 1 (LFA-1), consisting of CD11a and
CD18 subunits, plays an important role in T-cell activation and leukocyte extravasation. …

In 2003, the completion of the Human Genome Project (1) together with advances in
computational resources (2) were expected to launch an era where the genetic and genomic …