Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.
K Matsui, JJ Boniface, P Steffner… - Proceedings of the …, 1994 - National Acad Sciences
Recognition by T-cell antigen receptors (TCRs) of processed peptides bound to major
histocompatibility complex (MHC) molecules is required for the initiation of most T-lymphocyte …
histocompatibility complex (MHC) molecules is required for the initiation of most T-lymphocyte …
IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.
H Tsutsui, K Nakanishi, K Matsui… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
NK cells, non-T non-B immune effector lymphocytes, are localized in many organs, including
liver, as well as in the circulation. To investigate the regulatory mechanism of killing …
liver, as well as in the circulation. To investigate the regulatory mechanism of killing …
IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells
…, K Torigoe, M Kurimoto, K Matsui… - International …, 2000 - academic.oup.com
IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T h
1 response. IL-18 has a structural homology to IL-1, particularly IL-1β. IL-18R, composed of IL…
1 response. IL-18 has a structural homology to IL-1, particularly IL-1β. IL-18R, composed of IL…
Low affinity interaction of peptide-MHC complexes with T cell receptors
K Matsui, JJ Boniface, PA Reay, H Schild… - Science, 1991 - science.org
The interaction of antigen-specific T cell receptors (TCRs) with their ligands, peptides bound
to molecules of the major histocompatibility complex (MHC), is central to most immune …
to molecules of the major histocompatibility complex (MHC), is central to most immune …
[PDF][PDF] Caspase-1-independent, Fas/Fas ligand–mediated IL-18 secretion from macrophages causes acute liver injury in mice
…, K Kuida, H Nakano, N Hayashi, K Takeda, K Matsui… - Immunity, 1999 - cell.com
IL-18, produced as a biologically inactive precursor, is processed by caspase-1 in LPS-activated
macrophages. Here, we investigated caspase-1-independent processing of IL-18 in …
macrophages. Here, we investigated caspase-1-independent processing of IL-18 in …
Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with …
Background Biological disease-modifying anti-rheumatic drugs (bDMARDs) are recommended
for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when …
for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when …
Pathophysiological roles of interleukin-18 in inflammatory liver diseases.
H Tsutsui, K Matsui, H Okamura… - Immunological reviews, 2000 - europepmc.org
Innate immune response to microbes sometimes determines the nature of the following specific
immune response. Kupffer cells, a potent constituent of innate immunity, play a key role …
immune response. Kupffer cells, a potent constituent of innate immunity, play a key role …
IL-18 accounts for both TNF-alpha-and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.
When LPS is administered to heat-killed Propionibacterium acnes-primed BALB/c nude mice,
they develop endotoxin-induced liver injury. As previously reported, this liver injury can be …
they develop endotoxin-induced liver injury. As previously reported, this liver injury can be …
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
Y Hyodo, K Matsui, N Hayashi, H Tsutsui… - The Journal of …, 1999 - journals.aai.org
IL-18 is a powerful inducer of IFN-γ production, particularly in collaboration with IL-12. IL-18,
like IL-12, also augments NK activity. Here we investigated the molecular mechanism …
like IL-12, also augments NK activity. Here we investigated the molecular mechanism …
Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial
Background Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibody, has
previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing …
previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing …