HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom.

MA Brown, KD Pile, LG Kennedy, A Calin… - Annals of the …, 1996 - ard.bmj.com
OBJECTIVE: To investigate the HLA class I associations of ankylosing spondylitis (AS) in the
white population, with particular reference to HLA-B27 subtypes. METHODS: HLA-B27 and -…

Clinical pharmacokinetics and pharmacodynamics of febuxostat

B Kamel, GG Graham, KM Williams, KD Pile… - Clinical …, 2017 - Springer
Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …

HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.

P Wordsworth, KD Pile, JD Buckely… - American journal of …, 1992 - ncbi.nlm.nih.gov
We have investigated the role of HLA-DR genotypes in 184 patients with severe rheumatoid
arthritis (RA) and in 46 patients with Felty syndrome, to establish the relative contribution of …

The effect of HLA‐DR genes on susceptibility to and severity of ankylosing spondylitis

…, C Darke, K Gibson, KD Pile… - … : Official Journal of …, 1998 - Wiley Online Library
Objective To analyze the effect of HLA‐DR genes on susceptibility to and severity of
ankylosing spondylitis (AS). Methods Three hundred sixty‐three white British AS patients were …

A genome‐wide screen for susceptibility loci in ankylosing spondylitis

…, KD Pile, LG Kennedy, D Campbell… - … : Official Journal of …, 1998 - Wiley Online Library
Objective To localize the regions containing genes that determine susceptibility to ankylosing
spondylitis (AS). Methods One hundred five white British families with 121 affected sibling …

Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis

…, KD Pile, A Calin, A Ebringer, DE Weeks… - Human molecular …, 2000 - academic.oup.com
Ankylosing spondylitis (AS) is a common and highly familial rheumatic disorder. The sibling
recurrence risk ratio for the disease is 63 and heritability assessed in twins >90%. Although …

Understanding the dose–response relationship of allopurinol: predicting the optimal dosage

…, SL Stocker, I Portek, KD Pile… - British journal of …, 2013 - Wiley Online Library
Aims The aim of the study was to identify and quantify factors that control the plasma
concentrations of urate during allopurinol treatment and to predict optimal doses of allopurinol. …

Synovectomy of the elbow and radial head excision in rheumatoid arthritis: predictive factors and long-term outcome

NST Gendi, JMC Axon, AJ Carr, KD Pile… - The Journal of Bone …, 1997 - boneandjoint.org.uk
We carried out a survival analysis of elbow synovectomy (ES) and excision of the radial
head (RHE) performed on 171 rheumatoid elbows. The failure criteria were revision surgery (…

Randomized controlled trial of alendronate in airways disease and low bone mineral density

BJ Smith, LL Laslett, KD Pile… - Chronic respiratory …, 2004 - journals.sagepub.com
Background:Patients with airways disease have been demonstrated to be at risk of
osteoporosis, and this is likely to be multifactorial. Our aim was to identify patients with low bone …

Reactive joint symptoms following an outbreak of Salmonella typhimurium phage type 135a.

ATY Lee, RG Hall, KD Pile - The Journal of Rheumatology, 2005 - jrheum.org
OBJECTIVE: To quantify the incidence and clinical features of reactive arthritis (ReA) developing
in a cohort exposed to an outbreak of Salmonella typhimurium phage type 135a, and …