Background Inhibition of cholesteryl ester transfer protein (CETP) has been shown to have
a substantial effect on plasma lipoprotein levels. We investigated whether torcetrapib, a …

Method The authors conducted a randomized controlled trial (RCT) at 16 academic health
centers (June 2010 to July 2011). Faculty mentors of trainees who were conducting clinical/…

Objective. To examine the mortality and cardiovascular disease (CVD) burden among a
population-based cohort of patients with systemic lupus erythematosus (SLE) with previously …

Importance Bromodomain and extraterminal proteins are epigenetic regulators of gene
transcription. Apabetalone is a selective bromodomain and extraterminal protein inhibitor …

Background Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in heart
failure patients with reduced left ventricular function and intraventricular conduction delay. …

Background Testosterone treatment in men with hypogonadism improves bone density and
quality, but trials with a sufficiently large sample and a sufficiently long duration to determine …

Background Patients with diabetes and acute coronary syndrome (ACS) are at high risk for
subsequent heart failure. Apabetalone is a selective inhibitor of bromodomain and extra-…

Results Median follow-up was 27 months (interquartile range, 20–32 months). In participants
with CKD, apabetalone compared with placebo was associated with fewer major adverse …

… Drs Sesto, Chourasia, and Buhr received support from the University of Wisconsin Clinical
and Translational Science Award (NIH/NCRR 1 UL1RR025011). Dr Rabago was partially …

Objectives The Hoffmann method is a procedure for reference interval estimation using routine
clinical results. Many authors incorrectly prepare Hoffmann plots on a linear rather than …