Migration-stimulating factor: a genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells

…, R Baillie, K Seneviratne, J Clausen, K Motegi… - Cancer research, 2003 - AACR
Migration-stimulating factor (MSF) is a 70-kDa motogenic protein previously reported to be
expressed by fetal and cancer patient fibroblasts cultured in vitro and present in the serum of …

Enhanced radiosensitization and chemosensitization in NF‐κB‐suppressed human oral cancer cells via the inhibition of γ‐irradiation‐and 5‐FU‐induced production of …

…, M Azuma, Y Ashida, K Motegi… - … journal of cancer, 2004 - Wiley Online Library
We examined the mechanisms underlying the enhancement of radiosensitivity and chemosensitivity
to γ‐irradiation (IR) and 5‐Fluorouracil (5‐FU) in human oral carcinoma cells (B88) …

TNF‐α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation

Y Yamamura, K Motegi, K Kani… - Journal of cellular …, 2012 - Wiley Online Library
Sjögren's syndrome is a systemic autoimmune disease characterized by reductions in salivary
and lacrimal secretions. The mechanisms underlying these reductions remain unclear. …

Role of cytokines in the destruction of acinar structure in Sjögren's syndrome salivary glands.

M Azuma, K Motegi, K Aota, Y Hayashi… - … investigation; a journal …, 1997 - europepmc.org
Our aim in the present study was to understand the mechanism whereby specific destruction
of acinar but not ductal structure occurs in salivary glands in Sjögren's syndrome (SS). Thus…

Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-κB activity in human oral squamous cell carcinoma cells

T Tamatani, M Azuma, K Motegi… - International …, 2007 - spandidos-publications.com
We have already demonstrated that human head and neck cancer cells have significantly
enhanced levels of transcription factor nuclear factor (NF)-κB activity compared to their normal …

[HTML][HTML] γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the downregulation of the expression of NF-κB-regulated anti …

…, T Yamanoi, H Takano, K Motegi… - International …, 2013 - spandidos-publications.com
Taxanes, including docetaxel, are widely used for the treatment of squamous cell carcinoma
of the head and neck. However, the gastrointestinal toxicity of docetaxel has limited its high-…

TGF-β1 inhibits NF-κB activity through induction of IκB-α expression in human salivary gland cells: a possible mechanism of growth suppression by TGF-β1

M Azuma, K Motegi, K Aota, T Yamashita… - Experimental cell …, 1999 - Elsevier
Transforming growth factor (TGF)-β is the prototype of a large superfamily of signaling
molecules involved in the inhibition of proliferation of multiple epithelial cell types. Although …

[HTML][HTML] Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2′-deoxycytidine: a possibility …

K Motegi, M Azuma, T Tamatani, Y Ashida… - Laboratory …, 2005 - nature.com
The aim of the present study was to investigate the possibility that ductal cells, which preferentially
survive and/or proliferate in Sjögren's syndrome (SS) salivary glands of patients with …

Suppression of tumor necrosis factor α–induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down …

M Azuma, K Aota, T Tamatani, K Motegi… - … : Official Journal of …, 2002 - Wiley Online Library
Objective. Our previous results suggested that suppression of tumor necrosis factor(TNF)–induced
matrix metalloproteinase 9 (MMP-9) could prevent the destruction of acinar tissue in …

Frequency analysis of heart rate variability: a useful assessment tool of linearly polarized near-infrared irradiation to stellate ganglion area for burning mouth …

…, H Takano, K Kani, F Matsumoto, K Motegi… - Pain …, 2013 - academic.oup.com
Background Burning mouth syndrome (BMS) is characterized by the following subjective
complaints without distinct organic changes: burning sensation in mouth or chronic pain of …